040-0916/04 – Toxicology (Tox)

Gurantor departmentDepartment of Occupational and Process SafetyCredits10
Subject guarantorprof. RNDr. Pavel Danihelka, CSc.Subject version guarantorprof. RNDr. Pavel Danihelka, CSc.
Study levelpostgraduateRequirementChoice-compulsory type B
YearSemesterwinter + summer
Study languageEnglish
Year of introduction2021/2022Year of cancellation
Intended for the facultiesFBIIntended for study typesDoctoral
Instruction secured by
LoginNameTuitorTeacher giving lectures
DAN40 prof. RNDr. Pavel Danihelka, CSc.
Extent of instruction for forms of study
Form of studyWay of compl.Extent
Full-time Examination 20+0
Part-time Examination 20+0

Subject aims expressed by acquired skills and competences

The objectives of the toxicology course are as follows: After completing the course, the student will understand the principles of toxicology and specifically toxicology of occupational and environmental safety and toxicology of disasters, specifically major chemical accidents. He/she will understand the classification of hazardous chemicals with regard to the toxicity, genotoxicity and other health effects of hazardous substances, will be able to use the terminology of toxicology and will understand basic concepts and rules of protection from the effects of toxic substances, including knowledge of elementary regulation in this area. The student will be able to find and use information on various forms of toxicity of chemicals and other materials and to apply it to practical problems and plan and realize procedures for determining exposure. She/he will be able to integrate hazard and exposure information into risk characteristics.

Teaching methods

Individual consultations


Course Toxicology deals with the effects of hazardous chemicals, mainly of anthropogenic origin, on human health and with the principles of risk management in this field. It focuses mainly on occupational and environmental toxicology and addresses both acute toxic effects, important in the event of incidents and accidents, and chronic effects associated with long-term exposures in labour processes and the environment. The course will enable students to understand the issues of industrial and environmental toxicology, i.e. dangerous properties, typical dose-effect relationships, exposure scenarios and exposure determination and risk characterization related to different types of toxicity. Another part of the subject is an introduction to the principles of risk management of toxic substances.

Compulsory literature:

Comprehensive Toxicology, Volumes 1-14 (2nd Edition), Elsevier 2010, ISBN 978-0-08-046868-6, Electronic ISBN 978-0-08-046884-6 Luttrell, William E. Jederberg, Warren W. Still, Kenneth R.. (2008). Toxicology Principles for the Industrial Hygienist. American Industrial Hygiene Association (AIHA). Online version available at: http://app.knovel.com/hotlink/toc/id:kpTPIH0001/toxicology-principles/toxicology-principles

Recommended literature:

Brandenberger, H. Maes, R.A.A.. (1997). Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. De Gruyter. Online version available at: http://app.knovel.com/hotlink/toc/id:kpATCFPC01/analytical-toxicology/analytical-toxicology

Way of continuous check of knowledge in the course of semester

Student actively communicates with the lecturer and prepares written report/essay on agreed topic. She/he presents results and defence them in discussion. Theoretical knowledge is confirmed by examen.


Other requirements

Active orientation in literature. Active communication with lecturer.


Subject has no prerequisities.


Subject has no co-requisities.

Subject syllabus:

Definition of toxikology. Substances which are harmful to health and their effects. Systemic toxicity, carcinogenicity, mutagenicity, reproductive toxicity, teratogenicity, corrosivity, irritability, sensitization, endocrine disruptors. The paths of entry of poison into the organism and its fate in it. Toxicokinetics. Dose-effect relationship. Exposure tests. Calculation of toxicological risk. ERAQ-SAR. Acute, subchronic and chronic toxicity. Toxicology and epidemiological studies. Toxicity limits, methods of obtaining them. Toxicological databases, their validity and availability. Occupational toxicology, chronic toxic effects. Acute toxicology and toxicology of disasters. Poison classification, EINECS and GHS, relationship to REACH. Exposure - types of exposure, expression of exposure, exposure scenarios. Quantification of exposure. Use of exposure to determine risk characteristics. Risk characterisation. Physical-chemical methods of determination of toxicants in the environment, sensors.

Conditions for subject completion

Part-time form (validity from: 2021/2022 Winter semester)
Task nameType of taskMax. number of points
(act. for subtasks)
Min. number of pointsMax. počet pokusů
Examination Examination   3
Mandatory attendence participation:

Show history

Conditions for subject completion and attendance at the exercises within ISP:

Show history

Occurrence in study plans

Academic yearProgrammeBranch/spec.Spec.ZaměřeníFormStudy language Tut. centreYearWSType of duty
2024/2025 (P1032D020005) Fire Protection and Safety K English Ostrava Choice-compulsory type B study plan
2024/2025 (P1032D020005) Fire Protection and Safety P English Ostrava Choice-compulsory type B study plan
2023/2024 (P1032D020005) Fire Protection and Safety K English Ostrava Choice-compulsory type B study plan
2023/2024 (P1032D020005) Fire Protection and Safety P English Ostrava Choice-compulsory type B study plan
2022/2023 (P1032D020005) Fire Protection and Safety P English Ostrava Choice-compulsory type B study plan
2022/2023 (P1032D020005) Fire Protection and Safety K English Ostrava Choice-compulsory type B study plan

Occurrence in special blocks

Block nameAcademic yearForm of studyStudy language YearWSType of blockBlock owner

Assessment of instruction

Předmět neobsahuje žádné hodnocení.