040-0916/04 – Toxicology (Tox)
| Gurantor department | Department of Occupational and Process Safety | Credits | 10 |
| Subject guarantor | prof. RNDr. Pavel Danihelka, CSc. | Subject version guarantor | prof. RNDr. Pavel Danihelka, CSc. |
| Study level | postgraduate | Requirement | Choice-compulsory type B |
| Year | | Semester | winter + summer |
| | Study language | English |
| Year of introduction | 2021/2022 | Year of cancellation | |
| Intended for the faculties | FBI | Intended for study types | Doctoral |
Subject aims expressed by acquired skills and competences
The objectives of the toxicology course are as follows: After completing the course, the student will understand the principles of toxicology and specifically toxicology of occupational and environmental safety and toxicology of disasters, specifically major chemical accidents. He/she will understand the classification of hazardous chemicals with regard to the toxicity, genotoxicity and other health effects of hazardous substances, will be able to use the terminology of toxicology and will understand basic concepts and rules of protection from the effects of toxic substances, including knowledge of elementary regulation in this area. The student will be able to find and use information on various forms of toxicity of chemicals and other materials and to apply it to practical problems and plan and realize procedures for determining exposure. She/he will be able to integrate hazard and exposure information into risk characteristics.
Teaching methods
Individual consultations
Summary
Course Toxicology deals with the effects of hazardous chemicals, mainly of anthropogenic origin, on human health and with the principles of risk management in this field. It focuses mainly on occupational and environmental toxicology and addresses both acute toxic effects, important in the event of incidents and accidents, and chronic effects associated with long-term exposures in labour processes and the environment. The course will enable students to understand the issues of industrial and environmental toxicology, i.e. dangerous properties, typical dose-effect relationships, exposure scenarios and exposure determination and risk characterization related to different types of toxicity. Another part of the subject is an introduction to the principles of risk management of toxic substances.
Compulsory literature:
Recommended literature:
Brandenberger, H. Maes, R.A.A.. (1997). Analytical Toxicology for Clinical, Forensic and Pharmaceutical Chemists. De Gruyter. Online version available at:
http://app.knovel.com/hotlink/toc/id:kpATCFPC01/analytical-toxicology/analytical-toxicology
Additional study materials
Way of continuous check of knowledge in the course of semester
Student actively communicates with the lecturer and prepares written report/essay on agreed topic. She/he presents results and defence them in discussion. Theoretical knowledge is confirmed by examen.
E-learning
Other requirements
Active orientation in literature.
Active communication with lecturer.
Prerequisities
Subject has no prerequisities.
Co-requisities
Subject has no co-requisities.
Subject syllabus:
Definition of toxikology. Substances which are harmful to health and their effects. Systemic toxicity, carcinogenicity, mutagenicity, reproductive toxicity, teratogenicity, corrosivity, irritability, sensitization, endocrine disruptors. The paths of entry of poison into the organism and its fate in it.
Toxicokinetics. Dose-effect relationship. Exposure tests. Calculation of toxicological risk. ERAQ-SAR. Acute, subchronic and chronic toxicity. Toxicology and epidemiological studies. Toxicity limits, methods of obtaining them. Toxicological databases, their validity and availability. Occupational toxicology, chronic toxic effects. Acute toxicology and toxicology of disasters. Poison classification, EINECS and GHS, relationship to REACH.
Exposure - types of exposure, expression of exposure, exposure scenarios. Quantification of exposure. Use of exposure to determine risk characteristics. Risk characterisation.
Physical-chemical methods of determination of toxicants in the environment, sensors.
Conditions for subject completion
Occurrence in study plans
Occurrence in special blocks
Assessment of instruction
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