546-0158/01 – Industrial Toxicology and Ecotoxicology (PTE)

Gurantor departmentDepartment of Environmental EngineeringCredits4
Subject guarantordoc. Mgr. Eva Pertile, Ph.D.Subject version guarantordoc. Mgr. Eva Pertile, Ph.D.
Study levelundergraduate or graduateRequirementCompulsory
Study languageCzech
Year of introduction2022/2023Year of cancellation
Intended for the facultiesHGFIntended for study typesFollow-up Master
Instruction secured by
LoginNameTuitorTeacher giving lectures
PER34 doc. Mgr. Eva Pertile, Ph.D.
SIM0235 Ing. Bohdana Šimáčková
Extent of instruction for forms of study
Form of studyWay of compl.Extent
Full-time Credit and Examination 2+2
Part-time Credit and Examination 8+8

Subject aims expressed by acquired skills and competences

The aim of the course is to acquaint students with the influence of industry on man and his environment. Knowledge: The student will gain knowledge and acquire terminology in the field of industrial toxicology. They will understand and be able to describe the toxicological effects of selected hazardous substances. They can describe the values ​​of NOEL, LOEL, NOAEL, LOAEL, the principle of their determination. Gain knowledge of current legislation in the protection of health when working with chemicals and preparations. Skills: The student will know the rules of classification and labelling of hazardous substances and mixtures. Can describe the factors influencing the effects of substances on the human body; be familiar with the legislation of the Czech Republic and the EU in the field of substances and mixtures, protection of public health and safety and health at work. Can describe the principles of risk assessment and health protection when working with substances and mixtures, procedures in accidents related to exposure to substances and mixtures; describe the hazardous properties of important inorganic and organic substances. Can navigate sources of information on the hazardous properties of substances and mixtures, work with materials that provide rules for optimizing operations; draw up operating rules.

Teaching methods



The course focuses on the toxic effects of raw materials, intermediates, products and wastes in the industry on humans, especially in relation to environmental and occupational exposures and risks. Attention is also paid to determining the risks to the biosphere arising from human industrial activity. The essence of the course is knowledge about the effects of individual groups of substances on the human body and knowledge about which toxic substances are produced by which industry. An integral part of the course is legislation in the field of chemical safety and prevention.

Compulsory literature:

POHANISH, Richard P. a Marshall SITTIG. [i]Sittig's handbook of toxic and hazardous chemicals and carcinogens[/i]. 6th ed. Waltham, MA: William Andrew, c2012. ISBN 978-1-4377-7869-4. HODGSON, Ernest. [i]A textbook of modern toxicology[/i]. 3rd ed. Hoboken, N.J.: John Wiley, c2004. ISBN 0-471-26508-x. ROBINSON, Laura a Ian THORN. [i]Toxicology and ecotoxicology in chemical safety assessment[/i]. Malden, MA: Blackwell Pub., 2005. ISBN 978-1-405-11559-9. WILLIAMS, Phillip L., Robert C. JAMES a Stephen M. ROBERTS. [i]Principles of toxicology: environmental and industrial applications[/i]. 2nd ed. New York: Wiley, 2000. ISBN 0-471-29321-0.

Recommended literature:

CARSON, P. A. a C. J. MUMFORD. [i]Hazardous chemicals handbook[/i]. 2nd ed. Boston: Butterworth-Heinemann, 2002. ISBN 0-7506-4888-0. GREIM, H. a R. SNYDER (Ed.). [i]Toxicology and Risk Assessment: A Com prehensive Introduction[/i]. John Wiley & Sons, Ltd. 2008. ISBN: 978-0-470-86893-5. MCDERMOTT, Henry J. a Shirley A. NESS. [i]Air monitoring for toxic exposures[/i]. 2nd ed. Hoboken, N.J.: Wiley-Interscience, c2004. ISBN 0-471-45435-4. GOWDER, Sivakumar, ed. [i]New Insights into Toxicity and Drug Testing[/i]. InTech, 2013. DOI: 10.5772/55886. ISBN 978-953-51-0946-4.

Way of continuous check of knowledge in the course of semester

Checking knowledge during the semester in consultations. The student's knowledge is verified in writing, with emphasis on understanding the topic and the application of theoretical knowledge in solving practical problems. The evaluation also includes collective evaluation and self-evaluation. The overall work includes students' active work in class. Written and oral exam.


Other requirements

Active participation in seminars, proven successful processing of individual tasks, continuously awarded in the semester.


Subject has no prerequisities.


Subject has no co-requisities.

Subject syllabus:

1. Introduction to industrial and environmental toxicology; literature, information sources; definitions, dose-effect relationship, toxicity, substance interactions at different levels; toxicokinetics; bioavailability, etc. 2. Principles of toxicology related to industry and the environment; dose-response; toxicity mechanisms, hazard assessment principles. Hazardous physicochemical properties, their testing. Individual types of toxic effects and possibilities of influencing them. 3. Methods of classification of chemical substances in the Czech Republic and the EU. The current system of classification of substances hazardous to health and the environment and risk assessment system. Safety of chemical products, some internationally monitored groups of chemical substances. Current chemical legislation 4. Introduction to the toxicology of the main classes of industrial and environmental compounds. Testing and evaluation of ecotoxicity and other properties dangerous for the environment, substances and mixtures dangerous for the environment. 5. Origin and types of waste in industrial production. Chemical properties of waste from industrial production. Hazardous substances in waste, hygienic and toxicological aspects of the generation, use and disposal of waste, management of hazardous waste from industrial production. 6. Endocrine disruptors and their health risks. Types and occurrence of endocrine disruptors. Bioassays. Immunosuppressors. 7. Biocidal substances; insecticides, rodenticides, pesticides. Antibacterial agents. Antibiotics. Antifungals. Virostatics. Protozoal biocides. Cytostatics. Antiseptics. Effects on humans and the environment. 8. Drugs in the environment. Indirect exposure to the human population. Sources of emissions. Ecotoxicology of drugs. 9. Ecotoxically important environmental pollutants (oxides of sulfur, nitrogen, ozone, nitrates, cyanides, PAHs, PCBs, dioxins, other pollutants from industrial production) and their monitoring. Pollutant cycle in the environment. 10. Substances produced by industry and their occurrence in plants. Protective and preventive measures in industrial production. Determination of toxic properties from the literature: toxicological data (LD, LC, NOAEL, LOAEL, etc.), toxicological databases, safety data sheets. 11. Toxicological characteristics of organic compounds, organoelement and organometallic compounds - mechanism of interaction in the organism and the environment, transport and metabolism. 12. Toxicology of industrial raw materials, intermediate products, products and waste pollutants in selected organic technological processes. Toxicologically important organic substances (benzene, asbestos, glycols, vinyl chloride, products of the petrochemical industry, etc.) in the work environment: occurrence, side effects and prevention. 13. Toxicological characteristics of elements, hazardous metals, inorganic compounds in selected technological processes (production of acids, bases, salts, ammonia, fertilizers, etc.). Toxicologically important metals in the work environment: occurrence, side effects and prevention. 14. Pollution by toxic elements from mineral processing: occurrence, side effects and prevention.

Conditions for subject completion

Full-time form (validity from: 2022/2023 Summer semester)
Task nameType of taskMax. number of points
(act. for subtasks)
Min. number of pointsMax. počet pokusů
Credit and Examination Credit and Examination 100 (100) 51
        Credit Credit 30 (30) 15
                Semestrální projekt Semestral project 30  15
        Examination Examination 70  35 3
Mandatory attendence participation: 28 hours of lectures + 28 hours of exercises

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Conditions for subject completion and attendance at the exercises within ISP: As part of the ISP, the student is obliged to participate in individual consultations, which will be conducted in the form of a discussion on the topics studied. Exercise: The student submits a semester project on a topic that will be assigned to him at the beginning of the semester.

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Occurrence in study plans

Academic yearProgrammeField of studySpec.ZaměřeníFormStudy language Tut. centreYearWSType of duty
2022/2023 (N0724A290012) Environmental Protection within Industry P Czech Ostrava 1 Compulsory study plan
2022/2023 (N0724A290012) Environmental Protection within Industry K Czech Ostrava 1 Compulsory study plan

Occurrence in special blocks

Block nameAcademic yearForm of studyStudy language YearWSType of blockBlock owner

Assessment of instruction

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