546-0332/01 – Toxicology (Toxi)
| Gurantor department | Department of Environmental Engineering | Credits | 6 |
| Subject guarantor | doc. Mgr. Eva Pertile, Ph.D. | Subject version guarantor | Fiktivní Uživatel |
| Study level | undergraduate or graduate | Requirement | Compulsory |
| Year | 2 | Semester | winter |
| | Study language | Czech |
| Year of introduction | 2005/2006 | Year of cancellation | 2007/2008 |
| Intended for the faculties | HGF | Intended for study types | Bachelor |
Subject aims expressed by acquired skills and competences
The objective of this course is to get a an overview on basic toxicology. After completing this course the student orients in basics of general and experimental toxicology, knows toxic effects of selected substances, including their mechanism of action and the possibility of reducing the risk and consequences of intoxication.
Teaching methods
Lectures
Project work
Other activities
Summary
Interaction of pollutants with living organisms, biotransformation of xenobiotics. Summary of toxicology of inorganic and organic substances. Ecotoxicological testing and evaluation of substances and wastes. Legislation on chemicals and hazardous wastes. Classification and registration of chemical substances and preparations under EU and CR. Sources of toxicological and ecotoxicological information.
Compulsory literature:
WALKER, C.H., Principles of ecotoxicology, Ed. Taylor and Francis, London, 2001.
Recommended literature:
ECOBICHON, J. D.: The Basis of Toxicity Trstiny, CRC Press, Boca Raton 1997.
STONE, T., DARLINGTON G.: Pills, Potions and Poisons, Oxford University Press, 2000.
Additional study materials
Way of continuous check of knowledge in the course of semester
Tutorial within the range of lectures for students of combination forms studies.
E-learning
Other requirements
Prerequisities
Subject has no prerequisities.
Co-requisities
Subject has no co-requisities.
Subject syllabus:
1. Current data of toxicology conception, case - history, toxicology classification , characteristic of branch. Toxicology concept in wider context of natural sciences, determination of basic conceptions, case history.
2. Definition of terms. Toxic matter and toxicity. Toxic effects (characteristic, formulation). Poisons classification and their incidence on organism. Exposition.
3. Dose (relation dose and effect). Interaction between toxic matters. Factors of influencing toxic effect.
4. Management techniques of determination toxicity matters, bio-transformation conversion. Bio-transformation (axioms, phase, factors influencing bio - transformation).
5. Toxocinetics - interaction of toxic matters with organism (primary contact, absorption, distribution and transport toxic matters in organism, elimination).
6. Toxicology at molecules and cell level. Mechanism of penetration toxic matters over bio-membrane. Effects of noxas on organ level (mechanism, symptom effect, example of matters).
7. Mutagenesis, carcinogenese, reproductive and evolutional toxicity. Method assesment levels of exposition, exposition limits.
8. Significant inorganic harmful substances and their effects on organism.
9. Significant organic harmful matters and their effects.
10. Safety factor of work in chemistry, law regulations, source of information.
11. Chemical waste liquidation in laboratory. Legislative regulations and paper determinative treatment of chemical materials, labour protection.
12. Principals of first help at accident and poisonings in laboratory.
13. Present - day problems in environment.
Conditions for subject completion
Occurrence in study plans
Occurrence in special blocks
Assessment of instruction
Předmět neobsahuje žádné hodnocení.