546-0332/01 – Toxicology (Toxi)

Gurantor departmentDepartment of Environmental EngineeringCredits6
Subject guarantordoc. Mgr. Eva Pertile, Ph.D.Subject version guarantorFiktivní Uživatel
Study levelundergraduate or graduateRequirementCompulsory
Study languageCzech
Year of introduction2005/2006Year of cancellation2007/2008
Intended for the facultiesHGFIntended for study typesBachelor
Instruction secured by
LoginNameTuitorTeacher giving lectures
PER34 doc. Mgr. Eva Pertile, Ph.D.
Extent of instruction for forms of study
Form of studyWay of compl.Extent
Part-time Credit and Examination 14+0

Subject aims expressed by acquired skills and competences

The objective of this course is to get a an overview on basic toxicology. After completing this course the student orients in basics of general and experimental toxicology, knows toxic effects of selected substances, including their mechanism of action and the possibility of reducing the risk and consequences of intoxication.

Teaching methods

Project work
Other activities


Interaction of pollutants with living organisms, biotransformation of xenobiotics. Summary of toxicology of inorganic and organic substances. Ecotoxicological testing and evaluation of substances and wastes. Legislation on chemicals and hazardous wastes. Classification and registration of chemical substances and preparations under EU and CR. Sources of toxicological and ecotoxicological information.

Compulsory literature:

WALKER, C.H., Principles of ecotoxicology, Ed. Taylor and Francis, London, 2001.

Recommended literature:

ECOBICHON, J. D.: The Basis of Toxicity Trstiny, CRC Press, Boca Raton 1997. STONE, T., DARLINGTON G.: Pills, Potions and Poisons, Oxford University Press, 2000.

Way of continuous check of knowledge in the course of semester

Tutorial within the range of lectures for students of combination forms studies.


Other requirements


Subject has no prerequisities.


Subject has no co-requisities.

Subject syllabus:

1. Current data of toxicology conception, case - history, toxicology classification , characteristic of branch. Toxicology concept in wider context of natural sciences, determination of basic conceptions, case history. 2. Definition of terms. Toxic matter and toxicity. Toxic effects (characteristic, formulation). Poisons classification and their incidence on organism. Exposition. 3. Dose (relation dose and effect). Interaction between toxic matters. Factors of influencing toxic effect. 4. Management techniques of determination toxicity matters, bio-transformation conversion. Bio-transformation (axioms, phase, factors influencing bio - transformation). 5. Toxocinetics - interaction of toxic matters with organism (primary contact, absorption, distribution and transport toxic matters in organism, elimination). 6. Toxicology at molecules and cell level. Mechanism of penetration toxic matters over bio-membrane. Effects of noxas on organ level (mechanism, symptom effect, example of matters). 7. Mutagenesis, carcinogenese, reproductive and evolutional toxicity. Method assesment levels of exposition, exposition limits. 8. Significant inorganic harmful substances and their effects on organism. 9. Significant organic harmful matters and their effects. 10. Safety factor of work in chemistry, law regulations, source of information. 11. Chemical waste liquidation in laboratory. Legislative regulations and paper determinative treatment of chemical materials, labour protection. 12. Principals of first help at accident and poisonings in laboratory. 13. Present - day problems in environment.

Conditions for subject completion

Part-time form (validity from: 1960/1961 Summer semester, validity until: 2017/2018 Winter semester)
Task nameType of taskMax. number of points
(act. for subtasks)
Min. number of pointsMax. počet pokusů
Exercises evaluation and Examination Credit and Examination 100 (100) 51 3
        Exercises evaluation Credit 45 (45) 20 3
                Other task type Other task type 45  0 3
        Examination Examination 55 (55) 30 3
                Written examination Written examination 25  0 3
                Oral Oral examination 30  0 3
Mandatory attendence participation: Compulsory participation in exercises. Active participation in lectures.

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Conditions for subject completion and attendance at the exercises within ISP:

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Occurrence in study plans

Academic yearProgrammeBranch/spec.Spec.ZaměřeníFormStudy language Tut. centreYearWSType of duty
2006/2007 (B2102) Mineral Raw Materials (3904R022) Waste Treatment and Disposal K Czech Ostrava 2 Compulsory study plan
2006/2007 (B2102) Mineral Raw Materials (3904R022) Waste Treatment and Disposal K Czech Most 2 Compulsory study plan
2005/2006 (B2102) Mineral Raw Materials (3904R022) Waste Treatment and Disposal K Czech Ostrava 2 Compulsory study plan
2005/2006 (B2102) Mineral Raw Materials (3904R022) Waste Treatment and Disposal K Czech Most 2 Compulsory study plan

Occurrence in special blocks

Block nameAcademic yearForm of studyStudy language YearWSType of blockBlock owner

Assessment of instruction

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