546-0332/02 – Toxicology (Toxi)
Gurantor department | Department of Environmental Engineering | Credits | 5 |
Subject guarantor | doc. Mgr. Eva Pertile, Ph.D. | Subject version guarantor | doc. Mgr. Eva Pertile, Ph.D. |
Study level | undergraduate or graduate | Requirement | Compulsory |
Year | 2 | Semester | winter |
| | Study language | Czech |
Year of introduction | 2007/2008 | Year of cancellation | 2016/2017 |
Intended for the faculties | HGF | Intended for study types | Bachelor |
Subject aims expressed by acquired skills and competences
The objective of this course is to get a an overview on basic toxicology. After completing this course the student orients in basics of general and experimental toxicology, knows toxic effects of selected substances, including their mechanism of action and the possibility of reducing the risk and consequences of intoxication.
Teaching methods
Lectures
Project work
Other activities
Summary
Interaction of pollutants with living organisms, biotransformation of xenobiotics. Summary of toxicology of inorganic and organic substances. Ecotoxicological testing and evaluation of substances and wastes. Legislation on chemicals and hazardous wastes. Classification and registration of chemical substances and preparations under EU and CR. Sources of toxicological and ecotoxicological information.
Compulsory literature:
WALKER, C.H., Principles of ecotoxicology, Ed. Taylor and Francis, London, 2001.
Recommended literature:
ECOBICHON, J. D.: The Basis of Toxicity Trstiny, CRC Press, Boca Raton 1997.
STONE, T., DARLINGTON G.: Pills, Potions and Poisons, Oxford University Press, 2000.
Way of continuous check of knowledge in the course of semester
Consultations within the range of lectures for students of the combined form of study.
E-learning
Other requirements
Active participation in lectures and seminars.
Prerequisities
Subject has no prerequisities.
Co-requisities
Subject has no co-requisities.
Subject syllabus:
1. The current concept of toxicology, history, toxicology classification , characteristics of branches. The concept of toxicology in a broader context of science, the definition of basic terms, history.
2. Definition of terms. Toxic material and toxicity. Toxic effects (characteristics, formulations). Poison classification and their effects on organisms. Exposition.
3. Dose (the dose-effect relation). Interaction between toxic matters. Factors influencing toxic effect.
4. Methods of determining the toxicity of substances, biotransformation conversion. Biotransformation (principle, phase, factors affecting biotransformation).
5. Toxocinetics - interaction of a toxic substance with an organism (primary contact, absorption, distribution and transport of toxic substances in the body, excretion).
6. Toxicology at the level of molecules and cells. The mechanism of penetration of toxic substances through biomembranes. Effects of pollutants at the organ level (mechanism, effects, examples of substances).
7. Mutagenesis, carcinogenesis, reproductive and developmental toxicity. Methods for determining the level of exposure, exposure limits.
8. Significant inorganic pollutants and their effects on the body. Basic risk characteristics and toxicological properties of elements and inorganic compounds.
9. Significant organic pollutants and their effects. Basic risk characteristics and toxicological properties of organic compounds.
10. Safety in chemistry, law, information sources. Risks of working with poisons, flammable and explosive substances.
11. Disposal of chemical waste in the laboratory. Legislative regulations and documents defining the handling with chemicals, labour safety. Familiarization with information systems and resources in toxicology.
12. First aid for injuries and poisonings in the laboratory.
13. Current environmental issues.
Conditions for subject completion
Occurrence in study plans
Occurrence in special blocks
Assessment of instruction