546-0411/01 – Toxicology (Tox)

Gurantor departmentDepartment of Environmental EngineeringCredits3
Subject guarantordoc. Mgr. Eva Pertile, Ph.D.Subject version guarantordoc. Mgr. Eva Pertile, Ph.D.
Study levelundergraduate or graduateRequirementChoice-compulsory
Study languageCzech
Year of introduction2004/2005Year of cancellation2008/2009
Intended for the facultiesHGFIntended for study typesFollow-up Master
Instruction secured by
LoginNameTuitorTeacher giving lectures
PER34 doc. Mgr. Eva Pertile, Ph.D.
Extent of instruction for forms of study
Form of studyWay of compl.Extent
Full-time Graded credit 2+0
Part-time Graded credit 6+0

Subject aims expressed by acquired skills and competences

Students got survey in base of toxicology. Listener after graduation subject orients in principle of common and experimental toxicology, knows toxic effects of choice matter, including mechanism of their incidence and possibility limitation hazards or effect intoxication.

Teaching methods


Lecture from toxicology serves basic survey about toxicology for students of all specialization. Historical development of toxicology, partition, content and purposes. Includes common and special toxicology, legislative and rules of safeness work in chemical laboratory. In common toxicology: common interpretation toxicity of chemical substances, dependence effect on tax, toxic indices, print interactive coaming, gadgetry and manifestations toxic effect). Next part of lecture is devoted to legislative, concerning chemical materials and work with them.

Compulsory literature:

1. COCKERHAM, L. G., SHANE, B. S.: Basic Environmental Toxikology, CRC Press, Boca Raton, 1994. 2. WALKER, C.H., Principles of ecotoxicology, Ed. Taylor and Francis, London, 2001.

Recommended literature:

1. TIMBRELL, J. A.: Introduction to Toxikology. Tailor and Francis, London, 1995. 2. ECOBICHON, J. D.: The Basis of Toxicity Trstiny, CRC Press, Boca Raton 1997. 3. FRANCIS, B. M.: Toxic Substance in the Environment, J. Wiley and Sons, New York, 1994. 4. STONE, T., DARLINGTON G.: Pills, Potions and Poisons, Oxford University Press, 2000.

Way of continuous check of knowledge in the course of semester

Active attendance at lecture discussion, student regain classified credit on base of elaborate seminar work and her presentation. Combination form of study: Tutorial within the range of lectures for students of combination form study.


Other requirements


Subject has no prerequisities.


Subject has no co-requisities.

Subject syllabus:

1. Current data of toxicology conception, case - history, toxicology classification , characteristic of branch. Toxicology concept in wider context of natural sciences, determination of basic conceptions, case history. 2. Definition of terms. Toxic matter and toxicity. Toxic effects (characteristic, formulation). Poisons classification and their incidence on organism. Exposition. 3. Dose (relation dose and effect). Interaction between toxic matters. Factors of influencing toxic effect. 4. Management techniques of determination toxicity matters, bio-transformation conversion. Bio-transformation (axioms, phase, factors influencing bio - transformation). 5. Toxocinetics - interaction of toxic matters with organism (primary contact, absorption, distribution and transport toxic matters in organism, elimination). 6. Toxicology at molecules and cell level. Mechanism of penetration toxic matters over bio-membrane. Effects of noxas on organ level (mechanism, symptom effect, example of matters). 7. Mutagenesis, carcinogenese, reproductive and evolutional toxicity. Method assesment levels of exposition, exposition limits. 8. Significant inorganic harmful substances and their effects on organism. 9. Significant organic harmful matters and their effects. 10. Safety factor of work in chemistry, law regulations, source of information. 11. Principals of first help at accident and poisonings in laboratory 12. – 13. Ecotoxicology. 14. Present - day problems in environmentu.

Conditions for subject completion

Full-time form (validity from: 1960/1961 Summer semester)
Task nameType of taskMax. number of points
(act. for subtasks)
Min. number of points
Graded exercises evaluation Graded credit 100 (100) 0
        Other task type Other task type 100  0
Mandatory attendence parzicipation:

Show history

Occurrence in study plans

Academic yearProgrammeField of studySpec.ZaměřeníFormStudy language Tut. centreYearWSType of duty
2008/2009 (N2102) Mineral Raw Materials (3904T005) Environmental Engineering P Czech Ostrava 2 Choice-compulsory study plan
2005/2006 (N2102) Mineral Raw Materials (3904T005) Environmental Engineering K Czech Most 1 Choice-compulsory study plan
2004/2005 (N2102) Mineral Raw Materials (3904T005) Environmental Engineering K Czech Ostrava 1 Choice-compulsory study plan

Occurrence in special blocks

Block nameAcademic yearForm of studyStudy language YearWSType of blockBlock owner