546-0411/01 – Toxicology (Tox)
| Gurantor department | Department of Environmental Engineering | Credits | 3 |
| Subject guarantor | doc. Mgr. Eva Pertile, Ph.D. | Subject version guarantor | doc. Mgr. Eva Pertile, Ph.D. |
| Study level | undergraduate or graduate | Requirement | Choice-compulsory |
| Year | 1 | Semester | winter |
| | Study language | Czech |
| Year of introduction | 2004/2005 | Year of cancellation | 2008/2009 |
| Intended for the faculties | HGF | Intended for study types | Follow-up Master |
Subject aims expressed by acquired skills and competences
Students got survey in base of toxicology. Listener after graduation subject orients in principle of common and experimental toxicology, knows toxic effects of choice matter, including mechanism of their incidence and possibility limitation hazards or effect intoxication.
Teaching methods
Summary
Lecture from toxicology serves basic survey about toxicology for students
of all specialization. Historical development of toxicology, partition, content
and purposes. Includes common and special toxicology, legislative and rules of safeness work in chemical laboratory. In common toxicology: common interpretation toxicity of chemical substances, dependence effect on tax, toxic indices, print interactive coaming, gadgetry and manifestations toxic effect). Next part of lecture is devoted to legislative, concerning chemical materials and work
with them.
Compulsory literature:
1. COCKERHAM, L. G., SHANE, B. S.: Basic Environmental Toxikology, CRC Press, Boca Raton, 1994.
2. WALKER, C.H., Principles of ecotoxicology, Ed. Taylor and Francis, London, 2001.
Recommended literature:
1. TIMBRELL, J. A.: Introduction to Toxikology. Tailor and Francis, London,
1995.
2. ECOBICHON, J. D.: The Basis of Toxicity Trstiny, CRC Press, Boca Raton 1997.
3. FRANCIS, B. M.: Toxic Substance in the Environment, J. Wiley and Sons, New
York, 1994.
4. STONE, T., DARLINGTON G.: Pills, Potions and Poisons, Oxford University Press, 2000.
Way of continuous check of knowledge in the course of semester
Active attendance at lecture discussion, student regain classified credit on base of elaborate seminar work and her presentation.
Combination form of study:
Tutorial within the range of lectures for students of combination form study.
E-learning
Other requirements
Prerequisities
Subject has no prerequisities.
Co-requisities
Subject has no co-requisities.
Subject syllabus:
1. Current data of toxicology conception, case - history, toxicology classification , characteristic of branch. Toxicology concept in wider context of natural sciences, determination of basic conceptions, case history.
2. Definition of terms. Toxic matter and toxicity. Toxic effects (characteristic, formulation). Poisons classification and their incidence on organism. Exposition.
3. Dose (relation dose and effect). Interaction between toxic matters. Factors of influencing toxic effect.
4. Management techniques of determination toxicity matters, bio-transformation conversion. Bio-transformation (axioms, phase, factors influencing bio - transformation).
5. Toxocinetics - interaction of toxic matters with organism (primary contact, absorption, distribution and transport toxic matters in organism, elimination).
6. Toxicology at molecules and cell level. Mechanism of penetration toxic matters over bio-membrane. Effects of noxas on organ level (mechanism, symptom effect, example of matters).
7. Mutagenesis, carcinogenese, reproductive and evolutional toxicity. Method assesment levels of exposition, exposition limits.
8. Significant inorganic harmful substances and their effects on organism.
9. Significant organic harmful matters and their effects.
10. Safety factor of work in chemistry, law regulations, source of information.
11. Principals of first help at accident and poisonings in laboratory
12. – 13. Ecotoxicology.
14. Present - day problems in environmentu.
Conditions for subject completion
Occurrence in study plans
Occurrence in special blocks
Assessment of instruction
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