547-0276/01 – Toxicology (Toxiko)

Gurantor departmentzrušenoCredits5
Subject guarantorprof. RNDr. Pavel Danihelka, CSc.Subject version guarantorprof. RNDr. Pavel Danihelka, CSc.
Study levelundergraduate or graduateRequirementCompulsory
Study languageCzech
Year of introduction1999/2000Year of cancellation2010/2011
Intended for the facultiesFBIIntended for study typesBachelor
Extent of instruction for forms of study
Form of studyWay of compl.Extent
Combined Credit and Examination 0+0

Subject aims expressed by acquired skills and competences

Student, after the course, understands biological risks in the sense of REACH an CLP Directives, will be able to work with concepts of acute toxicity, corrosivity, irritant properties, carcinogeneity, mutageneity, reproductive toxicity, sensibilization, ecotoxicity. She/he understands the relation dose/effect, the metric of dose under different conditions and will be able to find toxicological data of toxic substances.

Teaching methods


Toxicology definition, disciplines. Substances dangerous for health and their effects. Acute toxicity, corrosivity, irritant properties, carcinogeneity, mutageneity, reproductive toxicity, sensibilization, ecotoxicity. Exposure routes, toxicant fate. Toxicokinetic. Dose-effect and various metrics. Aciute, subchronic and chronic toxicity. Testing, including in-vigtro and in-silico methods. ERA.

Compulsory literature:

Direktivy REACH a CLP Health aspects of chemical accidents, guidance on chemical accident awareness, preparedness and response for health professionals and emergency responders, Organisation for Economic Co-operation and Development, OCDE/GD(94)1, Environment monography No. 81, Paris 1994,

Recommended literature:

Way of continuous check of knowledge in the course of semester


Další požadavky na studenta


Subject has no prerequisities.


Subject has no co-requisities.

Subject syllabus:

Industrial Toxicology as a scientific discipline and management system. Compounds dangerous for human health and their impacts: system toxicity, cancerogenity, mutageneicity, reproduction toxicity, teratogenity, corrosivity, irritant properties, environmental toxicity and other effects (endocrine disruptors, allergens, sensibilitation). Dose - response dependens, limits of dangerous compouns in working and living environment, risk assessment, information sources concerning industrially used chemicals

Conditions for subject completion

Combined form (validity from: 1960/1961 Summer semester)
Task nameType of taskMax. number of points
(act. for subtasks)
Min. number of points
Exercises evaluation and Examination Credit and Examination 100 (145) 51
        Examination Examination 100  0
        Exercises evaluation Credit 45  0
Mandatory attendence parzicipation:

Show history

Occurrence in study plans

Academic yearProgrammeField of studySpec.FormStudy language Tut. centreYearWSType of duty
2002/2003 (B3908) Fire Protection and Industrial Safety (3908R006) Fire Protection Engineering and Industrial Safety K Czech Ostrava 3 Compulsory study plan

Occurrence in special blocks

Block nameAcademic yearForm of studyStudy language YearWSType of blockBlock owner