547-0276/01 – Toxicology (Toxiko)
| Gurantor department | zrušeno | Credits | 5 |
| Subject guarantor | prof. RNDr. Pavel Danihelka, CSc. | Subject version guarantor | prof. RNDr. Pavel Danihelka, CSc. |
| Study level | undergraduate or graduate | Requirement | Compulsory |
| Year | 3 | Semester | winter |
| | Study language | Czech |
| Year of introduction | 1999/2000 | Year of cancellation | 2010/2011 |
| Intended for the faculties | FBI | Intended for study types | Bachelor |
Subject aims expressed by acquired skills and competences
Student, after the course, understands biological risks in the sense of REACH an CLP Directives, will be able to work with concepts of acute toxicity, corrosivity, irritant properties, carcinogeneity, mutageneity, reproductive toxicity, sensibilization, ecotoxicity. She/he understands the relation dose/effect, the metric of dose under different conditions and will be able to find toxicological data of toxic substances.
Teaching methods
Summary
Toxicology definition, disciplines. Substances dangerous for health and their effects. Acute toxicity, corrosivity, irritant properties, carcinogeneity, mutageneity, reproductive toxicity, sensibilization, ecotoxicity. Exposure routes, toxicant fate. Toxicokinetic. Dose-effect and various metrics. Aciute, subchronic and chronic toxicity. Testing, including in-vigtro and in-silico methods. ERA.
Compulsory literature:
Direktivy REACH a CLP
Health aspects of chemical accidents, guidance on chemical accident awareness, preparedness and response for health professionals and emergency responders, Organisation for Economic Co-operation and Development, OCDE/GD(94)1,
Environment monography No. 81, Paris 1994,
Recommended literature:
Way of continuous check of knowledge in the course of semester
E-learning
Other requirements
Prerequisities
Subject has no prerequisities.
Co-requisities
Subject has no co-requisities.
Subject syllabus:
Industrial Toxicology as a scientific discipline and management system. Compounds dangerous for human
health and their impacts: system toxicity, cancerogenity, mutageneicity,
reproduction toxicity, teratogenity, corrosivity, irritant properties,
environmental toxicity and other effects (endocrine disruptors, allergens,
sensibilitation). Dose - response dependens, limits of dangerous compouns in
working and living environment, risk assessment, information sources concerning
industrially used chemicals
Conditions for subject completion
Occurrence in study plans
Occurrence in special blocks
Assessment of instruction
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