617-3004/01 – Toxicology (Tox)
| Gurantor department | Department of Chemistry | Credits | 4 |
| Subject guarantor | prof. Ing. Petr Praus, Ph.D. | Subject version guarantor | prof. Ing. Petr Praus, Ph.D. |
| Study level | undergraduate or graduate | Requirement | Compulsory |
| Year | 1 | Semester | winter |
| | Study language | Czech |
| Year of introduction | 2015/2016 | Year of cancellation | 2020/2021 |
| Intended for the faculties | FMT | Intended for study types | Follow-up Master |
Subject aims expressed by acquired skills and competences
Course objectiv is submit complete information about the harmful and toxic effects of substances (organic and inorganic), basic concepts of the toxicity, teratogenity, mutagenity, etc. Subject matter is also focused on the toxicity of fungi, plants, animals, drugs, eventually chemical weapons. Aspects of conversion of toxic substances are explained as in the humans body with the individual processes. Part of course is also the legal site and toxicology valid norms, regulations, laws and regulations by the EU. Special attention is devoted to issue of ecotoxicology and tests according to OECD.
Teaching methods
Lectures
Tutorials
Experimental work in labs
Summary
The subject introduces students to the harmful with effects of chemicals and chemical products for humans (inorganic and organic compounds), the forms of entry of these substances in the body and more detailed metabolism. The subject also focuses on some areas of biochemistry, organic chemistry and biology in relation to toxicology, including first aid in case of involvement with these substances. Part of this subject is devoted to actions which take place in the human body, detailed procedures for removal of toxic substances, their effect on mutation, degeneration, carcinogenity, reproduction, mutagenity, as well as the influence of toxicity on the brain, liver, heart and other organs, etc., which breaks down toxic substances, including acute toxicity tests. Part of the subject is closely oriented on a more detailed interpretation on field that is devoted to molds and the associated toxic effects, including issues related to toxic mushrooms, drugs, medications and eventually warfare substances, including toxicology of plants. Further the subject introduces students to the applicable laws and associated regulations and regulations from the field of chemicals and chemical products, namely the existing bylaws Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labeling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006 (Text with EEA relevance) and the Law No. 345/2005 Coll., the law on waste, accidents, narcotics and psychotropic substances, etc. Another form are information on the utilization the application of knowledge in chemistry, eventually in other fields, what mean keeping records of chemicals, work and handling with these agents, provided first aid, safety issues, work with chemicals, etc.
Compulsory literature:
[1] Hodgson, E., Levi P.E.: A Textbook of Modern Toxicology. Elsevier Sci. Publ., New York, Amsterdam, London, 1987.
[2] Timbrell, J.A.: Introduction to Toxicology. The 2nd Edition. Taylor and Francis, London, 1994.
[3] http://eur-lex.europa.eu/Result.do?T1=V1&T2=2008&T3=1272&RechType=RECH_naturel&Submit=Search (Corrigendum to Regulation (EC) No. 1272/2008 of the European Parlament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No. 1907/2006 (OJ L 353, 31.12.2008)).
Recommended literature:
[1] Murray, L., Daly, F., Little, M., Cadogan, M.: Toxicology Handbook, Kindle Edition, Publisher: Churchill Livingstone Australia, 2010.
[2] http://toxnet.nlm.nih.gov/
Way of continuous check of knowledge in the course of semester
E-learning
Other requirements
Passing the the required number of theoretical and laboratory exercises and handing in of laboratory protocols.
Prerequisities
Subject has no prerequisities.
Co-requisities
Subject has no co-requisities.
Subject syllabus:
1. Introduction to toxicology, its structure and content. Poisons and other pollutants. Poisons in the history. Theory of toxicity. Routes of entry of substances into the body. Overview of the effects of poisons in the body. Acute and chronic effects of poisons in the body. General principles of treatment of poisoning.
2. The mechanism of effect of toxic substances, factors influencing the effects of toxic substances. Interaction of toxic substances in the body. Metabolism and disposal of toxins in the body, first aid for acute poisoning, the treatment of chronic poisoning. Preventive protection against exposure to toxic and harmful substances.
3. Biology and Biochemistry in relation to the toxicology of chemicals, the existing legislation relating to toxic and harmful to health substances, hygiene norms. Legislation Law: Corrigendum to Regulation (EC) No. 1272/2008 of the European Parlament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No. 1907/2006 (OJ L 353, 31.12.2008), Law No. 345/2005 Coll.
4. Degeneration, teratogenity, mutagenity of toxic substances,
5. Decree No. 362/2004 Coll. Classification and coding of toxicological properties and hazards of chemical substances and preparations. (H, P verdicts, eventually R, S sentences, etc.).
6. Toxicity of selected elements and inorganic compounds.
7. Toxicity of selected elements and inorganic compounds.
8. Toxicity of selected elements and inorganic compounds.
9. Toxicity of selected organic compounds.
10. Toxicity of selected organic compounds.
11. Toxicity of selected organic compounds. Ecotoxicology.
12. Chemical Ecotoxicology, OECD tests, toxicity of the living organisms (animals and plants), toxicity of alkaloids, molds, fungi, drugs, toxic effects from the industrial processing and toxicity of these manufactured products.
13. Toxicity of products - products for home and industrial utilization, eventually chemical weapons.
Conditions for subject completion
Occurrence in study plans
Occurrence in special blocks
Assessment of instruction