651-2077/01 – Risks of nanomaterials (RZ)
| Gurantor department | Department of Chemistry and Physico-Chemical Processes | Credits | 4 |
| Subject guarantor | Prof. Mgr. Jana Kukutschová, Ph.D. | Subject version guarantor | Prof. Mgr. Jana Kukutschová, Ph.D. |
| Study level | undergraduate or graduate | Requirement | Compulsory |
| Year | 1 | Semester | summer |
| | Study language | Czech |
| Year of introduction | 2022/2023 | Year of cancellation | |
| Intended for the faculties | FMT | Intended for study types | Bachelor |
Subject aims expressed by acquired skills and competences
Graduate of the subject is able to define relevant parameters of nanomaterials contributing to their environmental and health risks. Futher, he/she can explain potential transport and exposure routes of nanomaterials, their potential biotransformation and bioaccumulation within their life cycle. Graduate is able to discuss single aspects of air, water and soil pollution and also the topic of occupational safety of nanomaterials and nanomaterials in form of wastes. Furthermore, he/she can generally describe potential adverse effects of exposure of living organisms to nanomaterials on molecular, cellular and organ level. With respect to nanomaterials applications he/she is able to outline possible ethical issues of selected applications and pre-application assessment of nanomaterials and also to describe legislative framework of this topic.
Teaching methods
Lectures
Individual consultations
Project work
Summary
Předmět je zaměřen na prohloubení znalostí studentů v oblasti možných environmentálních a zdravotních rizik nanomateriálů spojených s jejich rostoucími aplikacemi v průmyslu, ale také každodenním světě, čímž roste jejich výskyt v prostředí. Předmět se zaobírá fyzikálně-chemickými parametry nanomateriálů, které ovlivňují účinky na živé organismy, ale také osud v životním prostředí. Podává komplexní pohled na experimentální metody testování toxicity, včetně metod charakterizace nanomateriálů pro potřeby interpretace výsledků toxikologického hodnocení. Součástí předmětu je také úvod do problematiky legislativního rámce používání a regulace nanomateriálů.
Compulsory literature:
Recommended literature:
Additional study materials
Way of continuous check of knowledge in the course of semester
Literární rešerše na vybrané téma a ústí zkouška formou prezentace literární rešerše.
E-learning
Other requirements
no other requirements
Prerequisities
Subject has no prerequisities.
Co-requisities
Subject has no co-requisities.
Subject syllabus:
1. Introduction to the subject: risk definition, risk assessment methods.
2. Hazardous parameters of nanomaterials: Why are they dangerous? Toxicologically relevant parameters of nanomaterials. Differences from the regular toxicology.
3. Occurence of nanomaterials in the environment – their origin and sources. Indoor nanmaterials. Nanomaterials in a workplace – occupational exposure.
4. Environmental fate of nanomaterials, life cycle assessment, nanomaterials release from nano-enabled products. Nanomaterials as wastes.
5. Environmental risks – air, water and soil pollution – case studies.
6. Exposure to nanomaterials – measurement (dosimetry), exposure routes, entrance of nanomaterials into an organism/cells, translocation, biotransformation, bioaccumulation, deposition in single target sites.
7. Interactions of nanomaterials with living organisms on molecular, cellular and organ level. Genotoxic effects, oxidative stress.
8. In vitro toxicity testing of nanomaterials – introdution to nanotoxicology.
9. In vivo, in silico methods of toxicity assessment/prediction of nanomaterials. Trends in nanomaterials toxicity assessment.
10. Selected biomedical, hygienic and environmental applications and their risks – case studies.
11. Ecotoxicity of nanomaterials – impact on organisms from different trophic levels. Impact on autotrophic and heterotrophic organisms, adverse effects on vital functions of plants and animals.
12. Health risks of nanomaterials – impact on tissues, organs, etc.
13. Health risks of nanomaterials – occupational exposure and safety.
14. Ethical aspects of nanomaterials use and current legislation framework for usage and regulation of nanomaterials.
Conditions for subject completion
Occurrence in study plans
Occurrence in special blocks
Assessment of instruction