660-2022/01 – Interaction of the material with the organism (IMO)
| Gurantor department | Centre for Advanced Innovation Technologies | Credits | 6 |
| Subject guarantor | Ing. Mgr. Daniel Cvejn, Ph.D. | Subject version guarantor | Ing. Mgr. Daniel Cvejn, Ph.D. |
| Study level | undergraduate or graduate | Requirement | Compulsory |
| Year | 1 | Semester | summer |
| | Study language | Czech |
| Year of introduction | 2024/2025 | Year of cancellation | |
| Intended for the faculties | FMT | Intended for study types | Bachelor |
Subject aims expressed by acquired skills and competences
The aim of the subject is to acquire knowledge enabling the graduate to understand, evaluate and possibly predict the safety parameters of the material. Furthermore, to know the risks of using certain materials, to evaluate their possible interaction with human physiology, especially in terms of their safety.
Teaching methods
Lectures
Seminars
Tutorials
Experimental work in labs
Summary
The subject profiles the student in the knowledge and risks of interaction of foreign material with an organism. It is divided into a general part, where general concepts of the interaction of materials with the organism are discussed in the form of basic knowledge from pharmacology, toxicology, (patho)physiology, immunology and (xeno)biochemistry and related scientific fields. This part is followed by a special (profile part) in which individual most commonly used materials are discussed and their advantages and risks are assessed based on concepts from the general part. As part of the course, the student will prepare a shorter seminar paper (up to 5 standard pages) on an assigned topic from a special thematic section, and its public presentation will be a condition for credit from the course.
Compulsory literature:
[1] Moore, W. J., Fyzikální chemie: příručka pro vysoké školy chemickotechnologické, SNTL, Praha, 1981
[2] Kellö, V., Tkáč, A., Fyzikálna chémia: vysokoškolská učebnica, Alfa, Bratislava, 1977
[3] Novák, J. a kol. Fyzikální chemie: bakalářský a magisterský kurz. VŠCHT, Praha, 2008
[4] Peřinová, K., Smetana, B., Zlá, S., Kostiuková, G., Teoretické základy fyzikální chemie v příkladech, VŠB,
Ostrava, 2018
[5] Atkins, P., de Paula, J., Physical Chemistry 9th Edition, Oxford University Press, New York, 2010
Recommended literature:
[1] Brdička, R., Základy fysikální chemie: vysokoškolská učebnice 2. vyd., Academia, Praha, 1977
[2] Silbey, R. J., Alberty, R. A., Bawendi, M. G., Physical chemistry 4th Edition. Wiley, USA, 2004
Way of continuous check of knowledge in the course of semester
Oral exam
E-learning
Other requirements
No further student requirements are required
Prerequisities
Subject has no prerequisities.
Co-requisities
Subject has no co-requisities.
Subject syllabus:
I. Block - General theory of interaction:
Week 1 – Body barriers – Compartment theory, main barriers/compartments, methods of transport of substances between them.
Week 2 – Basic toxicokinetic and toxicodynamic terms, basics of xenobiochemistry.
Week 3 – Toxicokinetics, basic toxicokinetic calculations.
Week 4 – Toxicity vs. pathogenicity of soluble substances, nanoparticles, microparticles and macroparticles.
Week 5 – Detoxification mechanisms of the organism.
Week 6 – Immune reaction to a foreign particle.
Week 7 – Macro (patho)physiological processes associated with foreign bodies.
II. Block - Special Theory of Interaction
Week 8 – Biocompatibility of metals with the organism – a macroscopic view.
Week 9 – Biocompatibility of metals with the organism – toxicological perspective.
10. Week – Biocompatibility of ceramic and other oxide materials.
11. Week – Biocompatibility of other inorganic materials.
12th Week – Biocompatibility of non-degradable polymers and composites.
13. Week - Biocompatibility and immunogenicity of biopolymers and degradable polymers.
14. Week – Biocompatibility and immunogenicity of carbonaceous materials.
Conditions for subject completion
Occurrence in study plans
Occurrence in special blocks
Assessment of instruction
Předmět neobsahuje žádné hodnocení.